Overview
Publication
Bioinformatics. 2013 Oct 15; 29(20):2653-4.
PubMed ID: 23926226
Title
nCal: An R package for non-linear calibration
Authors
Fong Y, Sebestyen K, Yu X, Gilbert P, Self S
Abstract
Non-linear calibration is a widely used method for quantifying biomarkers wherein concentration-response curves estimated using samples of known concentrations are used to predict the biomarker concentrations in the samples of interest. The R package nCal fills an important gap in the open source, stand-alone software for performing non-linear calibration. For curve fitting, nCal provides a new implementation of a robust, Bayesian hierarchical five-parameter logistic model. nCal supports a simple graphical user interface that can be used by laboratory scientists, and contains functionality for importing data from the multiplex bead array assay instrumentation.
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