Overview
Publication
Curr Opin HIV AIDS. 2017 May; 12(3):216-221.
PubMed ID: 28230655
Title
Lessons learned from human HIV vaccine trials
Authors
Pollara J, Easterhoff D, Fouda GG
Abstract
The ability to induce broadly neutralizing antibody (bNAb) responses is likely essential for development of a globally effective HIV vaccine. Unfortunately, human vaccine trials conducted to date have failed to elicit broad plasma neutralization of primary virus isolates. Despite this limitation, in-depth analysis of the vaccine-induced memory B-cell repertoire can provide valuable insights into the presence and function of subdominant B-cell responses, and identify initiation of antibody lineages that may be on a path towards development of neutralization breadth.
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