Overview
Publication
Curr Opin HIV AIDS. 2007 May; 2(3):183-8.
PubMed ID: 19372885
Title
Capturing viral diversity for in-vitro test reagents and HIV vaccine immunogen design
Authors
Brander C, Self S, Korber B
Abstract
HIV diversity is a major challenge to accurate detection of HIV-specific immunity in vitro and HIV vaccine immunogen design alike. Although achieving extensive coverage of global viral diversity is a common goal for both tasks, different strategies for achieving maximal in-vitro detection of responses and optimal in-vivo induction of immune responses may be needed. This review describes and compares some of the most recently developed approaches.
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