Overview
Publication
J Acquir Immune Defic Syndr. 2009 Aug 15; 51(5):536-45.
PubMed ID: 19512938
Title
The potential role of biomarkers in HIV preventive vaccine trials
Authors
Maclachlan E, Mayer KH, Barnabas R, Sanchez J, Koblin B, Duerr A
Abstract
Successful conduct of HIV vaccine efficacy trials entails identification and enrollment of at-risk populations, assessment of appropriate end points as measures of vaccine efficacy for prevention of HIV acquisition, and amelioration of disease course among infected vaccinees, as well as identification of potential confounders or effect modifiers. Although not invariably useful and bringing their own cost in terms of measurement and validation, a variety of biomarkers may aid at each stage of trial conduct.
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