Overview
Publication
PLOS ONE. 2012; 7(1):e29231.
PubMed ID: 22242162
Title
Safety and Immunogenicity of an HIV-1 Gag DNA Vaccine with or without IL-12 and/or IL-15 Plasmid Cytokine Adjuvant in Healthy, HIV-1 Uninfected Adults
Authors
Kalams SA , Parker S , Jin X , Elizaga M , Metch B, Wang, M, Hural J, Lubeck M, Eldridge J, Cardinali M, Blattner WA, Sobieszczyk M, Suriyanon V, Kalichman A, Weiner DB, Baden LR, the NIAID HIV Vaccine Trials Network
Abstract
DNA vaccines are a promising approach to vaccination since they circumvent the problem of vector-induced immunity. DNA plasmid cytokine adjuvants have been shown to augment immune responses in small animals and in macaques.
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