Overview
Publication
Curr Opin HIV AIDS. 2011 Sep; 6(5):427-34.
PubMed ID: 21734565
Title
Host genetic polymorphisms associated with innate immune factors and HIV-1
Authors
Sobieszczyk ME, Lingappa JR, McElrath MJ
Abstract
Our understanding of the early events in HIV-1 infection continues to grow, along with the heightened recognition of the important contribution that innate immunity plays in response to HIV-1. Here, we review the epidemiological and functional studies of genetic polymorphisms associated with innate immune factors that are believed to modulate host responses, focusing specifically on recent findings related to Toll-like receptor, cytokine, host restriction and KIR genes and their activities.
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