Overview
Publication
Curr Opin HIV AIDS. 2016 Nov; 11(6):620-627.
PubMed ID: 27662407
Title
Modeling HIV vaccine trials of the future
Authors
Gilbert PB, Huang Y, Janes HE
Abstract
Models of implementation of known-effective interventions for HIV prevention indicate that an efficacious vaccine to prevent HIV infection would be critical for controlling the HIV pandemic. Key issues in the design of future HIV vaccine trials are: first, how to develop reliable immunological correlates of vaccine efficacy, second, how to down-select candidate vaccine regimens into efficacy trials, and third, how to learn about vaccine efficacy in the context of the evolving HIV prevention landscape.
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