Overview
Publication
Hum Vaccin Immunother. 2014; 10(8):2507-11.
PubMed ID: 25424964
Title
Importance of neutralization sieve analyses when seeking correlates of HIV-1 vaccine efficacy
Authors
Montefiori DC
Abstract
This commentary describes a rationale for the use of breakthrough viruses from clinical trial participants to assess neutralizing antibodies as a correlate of HIV-1 vaccine efficacy. The rationale is based on principles of a genetic sieve analysis, where the 2 analyses may be cooperative for delineating neutralizing antibodies as a mechanistic correlate of protection.
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