Overview
Publication
J Infect Dis. 2016 Feb 15; 213(4):541-50.
PubMed ID: 26475930
Title
Vaccination with heterologous HIV envelope sequences and heterologous adenovirus vectors increases T cell responses to conserved regions (HVTN 083)
Authors
Walsh SR, Moodie Z, Fiore-Gartland AJ, Morgan C, Wilck MB, Hammer SM, Buchbinder SP, Kalams SA, Goepfert PA, Mulligan MJ, Keefer MC, Baden LR, Swann EM, Grant S, Ahmed H, Hertz T, Self SG, Friedrich D, Frahm N, Liao H-X, Montefiori DC, Tomaras GD, McElrath MJ, Hural J, Graham BS, Jin X, the HVTN 083 Study Group, and the NIAID HIV Vaccine Trials Network
Abstract
Increasing the breadth of human immunodeficiency virus type 1 (HIV-1) vaccine-elicited immune responses or targeting conserved regions may improve coverage of circulating strains. HIV Vaccine Trials Network 083 tested whether cellular immune responses with these features are induced by prime-boost strategies, using heterologous vectors, heterologous inserts, or a combination of both.
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