Overview
Publication
Curr Opin HIV AIDS. 2018 Mar; 13(2):128-136.
PubMed ID: 29266013
Title
Neutralization tiers of HIV-1
Authors
Montefiori DC, Roederer M, Morris L, Seaman MS
Abstract
HIV-1 isolates are often classified on the basis of neutralization 'tier' phenotype. Tier classification has important implications for the monitoring and interpretation of vaccine-elicited neutralizing antibody responses. The molecular basis that distinguishes the multiple neutralization phenotypes of HIV-1 has been unclear. We present a model based on the dynamic nature of the HIV-1 envelope glycoproteins and its impact on epitope exposure. We also describe a new approach for ranking HIV-1 vaccine-elicited neutralizing antibody responses.
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