Overview
Publication
Bioinformatics. 2017 Dec 1; 33(23):3824-3826.
PubMed ID: 28961740
Title
EMHP: an accurate automated hole masking algorithm for single-particle cryo-EM image processing
Authors
Berndsen Z, Bowman C, Jang H, Ward AB
Abstract
The Electron Microscopy Hole Punch (EMHP) is a streamlined suite of tools for quick assessment, sorting and hole masking of electron micrographs. With recent advances in single-particle electron cryo-microscopy (cryo-EM) data processing allowing for the rapid determination of protein structures using a smaller computational footprint, we saw the need for a fast and simple tool for data pre-processing that could run independent of existing high-performance computing (HPC) infrastructures. EMHP provides a data preprocessing platform in a small package that requires minimal python dependencies to function.
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