Overview
Publication
J Infect Dis. 2019 May 5; 219(11):1755-1765.
PubMed ID: 30615119
Title
Rapid boosting of HIV-1 neutralizing antibody responses in humans following a prolonged immunologic rest period
Authors
Spearman P, Tomaras GD, Montefiori DC, Huang Y, Elizaga ML, Ferrari G, Alam SM, Isaacs A, Ahmed H, Hural J, McElrath MJ, Ouedraogo L, Pensiero M, Butler C, Kalams SA, Overton ET, Barnett SW, HVTN 088 Protocol Team and the NIH/NIAID HIV Vaccine Trials Network
Abstract
The durability and breadth of human immunodeficiency virus type 1 (HIV-1)-specific immune responses elicited through vaccination are important considerations in the development of an effective HIV-1 vaccine. Responses to HIV-1 envelope subunit protein (Env) immunization in humans are often described as short-lived.
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