Overview
Publication
AIDS. 2018 Nov 28; 32(18):2669-2677.
PubMed ID: 30289807
Title
Metabolic pathway activation distinguishes transcriptional signatures of CD8+ T cells from HIV-1 elite controllers
Authors
Chowdhury FZ, Ouyang Z, Buzon M, Walker BD, Lichterfeld M, Yu XG
Abstract
Elite controllers, defined as persons maintaining undetectable levels of HIV-1 replication in the absence of antiretroviral therapy, represent living evidence that sustained, natural control of HIV-1 is possible, at least in relatively rare instances. Understanding the complex immunologic and virologic characteristics of these specific patients holds promise for inducing drug-free control of HIV-1 in broader populations of HIV-1 infected patients.
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