Overview
Publication
J Virol. 2019 Sep 1; 93(17):e00629-19.
PubMed ID: 31189712
Title
Revisiting the correlate of reduced HIV infection risk in the RV144 vaccine trial
Authors
Zolla-Pazner S, Gilbert PB
Abstract
The RV144 vaccine trial is the only clinical study to have shown a modest but statistically significant decrease in HIV infection risk. RV144 and the subsequent studies identifying the level of V1V2-specific antibodies as a correlate of reduced infection risk are still controversial despite many papers supporting and expanding the initial study. We address these controversies and summarize active-immunization and passive-immunization experiments in nonhuman primates that support the initial finding.
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