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Publications / Bekker 2020 (EClinicalMedicine)



EClinicalMedicine. 2020 Apr; 21(NA):100303.

PubMed ID: 32280940


Safety and tolerability of injectable Rilpivirine LA in HPTN 076: A phase 2 HIV pre-exposure prophylaxis study in women


Bekker LG, Li S, Pathak S, Tolley EE, Marzinke MA, Justman JE, Mgodi NM, Chirenje M, Swaminathan S, Adeyeye A, Farrior J, Hendrix CW, Piwowar-Manning E, Richardson P, Eshelman SH, Redinger H, Williams P, Sista ND, HPTN 076 Study Team


Daily oral TDF/FTC is protective against HIV infection when used for pre-exposure prophylaxis (PrEP). However, daily adherence to oral PrEP is difficult for many; therefore, finding alternative PrEP strategies remains a priority. HPTN 076 evaluated the long-acting injectable form of rilpivirine (RPV), known as RPV LA for safety, pharmacokinetics and acceptability.

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