Overview
Publication
J Virol. 2012 Oct; 86(20):11380-5.
PubMed ID: 22896600
Title
Memory CD4(+) T lymphocytes in the gastrointestinal tract are a major source of cell-associated simian immunodeficiency virus in chronic nonpathogenic infection of African green monkeys
Authors
Schmitz JE, Ma ZM, Hagan EA, Wilks AB, Furr KL, Linde CH, Zahn RC, Brenchley JM, Miller CJ, Permar SR
Abstract
Simian immunodeficiency virus (SIV) infection of natural hosts is characterized by nonpathogenic chronic viremia, maintenance of gastrointestinal epithelial barrier integrity, and low numbers of target cells. Assessment of cell-associated virus load in T cell subsets in multiple anatomic compartments of chronically SIV-infected sabeus African green monkeys (AGMs) revealed that gastrointestinal memory CD4(+) T lymphocytes are a major source of cell-associated virus and a significant contributor to SIV viremia in AGMs.
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