Overview
Publication
Virol J. 2012 Oct 2; 9(NA):226.
PubMed ID: 23031791
Title
Inhibition of HCV by the serpin antithrombin III
Authors
Asmal M, Seaman M, Lin W, Chung RT, Letvin NL, Geiben-Lynn R
Abstract
Although there have been dramatic strides made recently in the treatment of chronic hepatitis C virus infection, interferon-α based therapy remains challenging for certain populations, including those with unfavorable IL28B genotypes, psychiatric co-morbidity, HIV co-infection, and decompensated liver disease. We have recently shown that ATIII, a serine protease inhibitor (serpin), has broad antiviral properties.
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