Overview
Publication
J Virol. 2013 Oct; 87(20):11292-9.
PubMed ID: 23926337
Title
Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys
Authors
Ho C, Wu S, Amos JD, Colvin L, Smith SD, Wilks AB, Demarco CT, Brinkley C, Denny TN, Schmitz JE, Rodrigo AG, Permar SR
Abstract
Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs), rarely transmit SIV via breast-feeding. In order to examine the genetic diversity of breast milk SIV variants in this limited-transmission setting, we performed phylogenetic analysis on envelope sequences of milk and plasma SIV variants of AGMs. Low-diversity milk virus populations were compartmentalized from that in plasma. However, this compartmentalization was transient, as the milk virus lineages did not persist longitudinally.
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