Overview
Publication
J Virol. 2016 Jun 15; 90(12):5541-5548.
PubMed ID: 26962218
Title
Vaccination with live attenuated Simian Immunodeficiency Virus (SIV) protects from mucosal, but not necessarily intravenous, challenge with a minimally heterologous SIV
Authors
Sutton MS, Burns CM, Weiler AM, Balgeman AJ, Braasch A, Lehrer-Brey G, Friedrich TC, O'Connor SL
Abstract
Few studies have evaluated the impact of the viral challenge route on protection against a heterologous simian immunodeficiency virus (SIV) challenge. We vaccinated seven macaques with a live attenuated SIV that differed from SIVmac239Δnef by 24 amino acids, called m3KOΔnef. All animals were protected from an intrarectal SIVmac239 challenge, whereas only four animals were protected from subsequent intravenous SIVmac239 challenge. These data suggest that immune responses elicited by vaccination with live attenuated SIV in an individual animal can confer protection from intrarectal challenge while remaining insufficient for protection from intravenous challenge.
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