J Infect Dis. 2020 Nov 13; 222(12):2093-2102.
PubMed ID: 32060529
Antibody Fc glycosylation discriminates between latent and active tuberculosis
Lu LL, Das J, Grace PS, Fortune SM, Restrepo BI, Alter G
Mycobacterium tuberculosis remains a global health problem and clinical management is complicated by difficulty in discriminating between latent infection and active disease. While M. tuberculosis-reactive antibody levels are heterogeneous, studies suggest that levels of IgG glycosylation differ between disease states. Here we extend this observation across antibody domains and M. tuberculosis specificities to define changes with the greatest resolving power.
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