Overview
Publication
Vaccines (Basel). 2020 Dec 07; 8(4):NA.
PubMed ID: 33297341
Title
Intramuscular and intradermal electroporation of HIV-1 PENNVAX-GP DNA vaccine and IL-12 is safe, tolerable, acceptable in healthy adults
Authors
Edupuganti S, De Rosa SC, Elizaga M, Lu Y, Han X, Huang Y, Swann E, Polakowski L, Kalams SA, Keefer M, Maenza J, Wise MC, Yan J, Morrow MP, Khan AS, Boyer JD, Humeau L, White S, Sardesai NY, Bagarazzi M, Gilbert PB, Kublin JG, Corey L, Weiner DB, On Behalf Of The Hvtn Study Team, The Niaid-Funded Hiv Vaccine Trials Network
Abstract
Background: Several techniques are under investigation to improve the immunogenicity of HIV-1 DNA vaccine candidates. DNA vaccines are advantageous due to their ease of design, expression of multiple antigens, and safety.
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