Overview
Publication
J Acquir Immune Defic Syndr. 2020 Dec 01; 85(4):423-429.
PubMed ID: 33136739
Title
Model-based predictions of HIV incidence among african women using HIV risk behaviors and community-level data on male HIV prevalence and viral suppression
Authors
Moore JR, Donnell DJ, Boily MC, Mitchell KM, Delany-Moretlwe S, Bekker LG, Mgodi NM, El-Sadr W, Cohen MS, Celum CL, Dimitrov D
Abstract
Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate and emtricitabine has proven highly effective in preventing HIV acquisition and is therefore offered to all participants in the control group as part of the standard of care package in many new HIV prevention studies. We propose a methodology for predicting HIV incidence in a hypothetical ""placebo arm"" for open-label studies or clinical trials with active control among African women. We apply the method to an open-label PrEP study, HIV Prevention Trials Network 082, which tested strategies to improve PrEP adherence in young African women all of whom were offered PrEP.
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