Overview
Publication
Curr Opin HIV AIDS. 2010 Sep; 5(5):357-61.
PubMed ID: 20978374
Title
Overview of STEP and Phambili trial results: Two phase IIb test of concept studies investigating the MRK ad5 gag/pol/nef sub-type B HIV vaccine
Authors
Gray G, Buchbinder S, Duerr A.
Abstract
Two phase IIb test-of-concept studies evaluated the replication-defective adenovirus type 5 (Ad5) vaccine MRK gag/pol/nef HIV vaccine to prevent infection or decrease early plasma viral load in disparate populations. The STEP study enrolled men and women in the Americas, Caribbean and Australia; the Phambili trial enrolled men and women in South Africa, where the modes of sexual transmission and HIV-1 risk, subtypes of HIV-1, and background Ad5 seroprevalence differed.
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