Overview
Publication
BMC Genet. 2011 Apr 25; 12(NA):39.
PubMed ID: 21518453
Title
Empirical evaluations of analytical issues arising from predicting HLA alleles using multiple SNPs
Authors
Zhang XC, Li SS, Wang H, Hansen JA, Zhao LP
Abstract
Numerous immune-mediated diseases have been associated with the class I and II HLA genes located within the major histocompatibility complex (MHC) consisting of highly polymorphic alleles encoded by the HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1 loci. Genotyping for HLA alleles is complex and relatively expensive. Recent studies have demonstrated the feasibility of predicting HLA alleles, using MHC SNPs inside and outside of HLA that are typically included in SNP arrays and are commonly available in genome-wide association studies (GWAS). We have recently described a novel method that is complementary to the previous methods, for accurately predicting HLA alleles using unphased flanking SNPs genotypes. In this manuscript, we address several practical issues relevant to the application of this methodology.
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