Overview
Publication
PLOS ONE. 2012; 7(8):e43396.
PubMed ID: 22952672
Title
T-cell responses among HIV-infected persons after receipt of the MrkAd5/HIV gag/pol/nef vaccine: Their association with viral sequences and viral load measurements
Authors
Janes H, Frahm N, deCamp A, Rolland M, Gabriel E, Wolfson J, Hertz T, Kallas E, Goepfert P, Friedrich DP, Corey L, Mullins JI, McElrath MJ, Gilbert P
Abstract
The sieve analysis for the Step trial found evidence that breakthrough HIV-1 sequences for MRKAd5/HIV-1 Gag/Pol/Nef vaccine recipients were more divergent from the vaccine insert than placebo sequences in regions with predicted epitopes. We linked the viral sequence data with immune response and acute viral load data to explore mechanisms for and consequences of the observed sieve effect.
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