Overview
Publication
J Acquir Immune Defic Syndr. 2013 Jul 1; 63(3):263-71.
PubMed ID: 23392465
Title
Comprehensive assessment of HIV target cells in the distal human gut suggests increasing HIV susceptibility toward the anus
Authors
McElrath M, Smythe K, Randolph-Habecker J, Melton K, Goodpaster T, Hughes S, Mack M, Sato A, Diaz G, Steinbach G, Novak R, Curlin M, Lord J, Maenza J, Duerr A, Frahm N, Hladik F; the NIAID HIV Vaccine Trials Network
Abstract
Prevention of rectal HIV transmission is a high-priority goal for vaccines and topical microbicides because a large fraction of HIV transmissions occurs rectally. Yet, little is known about the specific target-cell milieu in the human rectum other than inferences made from the colon.
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