Overview
Publication
PLOS ONE. 2014 Nov 4; 9(11):e108631.
PubMed ID: 25369172
Title
Immune-correlates analysis of an HIV-1 vaccine efficacy trial reveals an association of nonspecific interferon-γ secretion with increased HIV-1 infection risk: A cohort-based modeling study
Authors
Huang Y, Duerr A, Frahm N, Zhang L, Moodie Z, DeRosa S, McElrath MJ, Gilbert PB
Abstract
Elevated risk of HIV-1 infection among recipients of an adenovirus serotype 5 (Ad5)-vectored HIV-1 vaccine was previously reported in the Step HIV-1 vaccine efficacy trial. We assessed pre-infection cellular immune responses measured at 4 weeks after the second vaccination to determine their roles in HIV-1 infection susceptibility among Step study male participants.
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