Overview
Publication
Clin Trials. 2015 Aug; 12(4):394-402.
PubMed ID: 25851992
Title
Testing the waters: Ethical considerations for including PrEP in a phase IIb HIV vaccine efficacy trial
Authors
Dawson L,Garner S, Anude C, Ndebele P, Karuna S, Holt R, Broder G, Handibode J, Hammer S, Sobieszczyk M, the NIAID HIV Vaccine Trials Network
Abstract
The field of HIV prevention research has recently experienced some mixed results in efficacy trials of pre-exposure prophylaxis, vaginal microbicides, and HIV vaccines. While there have been positive trial results in some studies, in the near term, no single method will be sufficient to quell the epidemic. Improved HIV prevention methods, choices among methods, and coverage for all at-risk populations will be needed. The emergence of partially effective prevention methods that are not uniformly available raises complex ethical and scientific questions regarding the design of ongoing prevention trials.
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