Overview
Publication
AIDS. 2007 Feb 19; 21(4):441-6.
PubMed ID: 17301562
Title
Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection
Authors
Bochud PY, Hersberger M, Taffe P, Bochud M, Stein CM, Rodrigues SD, Calandra T, Francioli P, Telenti A, Speck RF, Aderem A, Swiss HIV Cohort Study
Abstract
The clinical course of HIV-1 infection is highly variable among individuals, at least in part as a result of genetic polymorphisms in the host. Toll-like receptors (TLRs) have a key role in innate immunity and mutations in the genes encoding these receptors have been associated with increased or decreased susceptibility to infections.
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