Overview
Publication
Immunome Res. 2009 Feb 27; 5(NA):1.
PubMed ID: 19250530
Title
Genetic correlates of autoreactivity and autoreactive potential in human Ig heavy chains
Authors
Volpe JM, Kepler TB
Abstract
Immature bone marrow B cells are known to have longer CDR3 than mature peripheral B cells, and this genetic characteristic has been shown to correlate with autoreactivity in these early cells. B-cell Central tolerance eliminates these cells, but it is known that autoreactive B cells nevertheless appear commonly in healthy human blood. We examined over 7,300 Ig genes from Genbank, including those annotated by their discoverers as associated with autoreactivity, to determine the genetic correlates of autoreactivity in mature B cells.
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