Overview
Publication
Bioorg Med Chem Lett. 2008 Jul 15; 18(14):3906-9.
PubMed ID: 18586489
Title
Synthesis of all stereoisomers of KRN7000, the CD1d-binding NKT cell ligand
Authors
Park JJ, Lee JH, Ghosh SC, Bricard G, Venkataswamy MM, Porcelli SA, Chung SK
Abstract
KRN7000 is an important ligand identified for CD1d protein of APC, and KRN7000/CD1d complex can stimulate NKT cells to release Th1 and Th2 cytokines. In an effort to understand the structure-activity relationships, we have carried out the synthesis of a complete set of the eight KRN7000 stereoisomers, and their biological activities have been examined.
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