Overview
Publication
J Infect Dis. 2007 Nov 1; 196(9):1304-12.
PubMed ID: 17922394
Title
A framework for assessing immunological correlates of protection in vaccine trials
Authors
Qin L, Gilbert PB, Corey L, McElrath MJ, Self SG
Abstract
A central goal of vaccine research is to identify a vaccine-induced immune response that predicts protection from infection or disease. The term ""correlate of protection"" has been used to refer to at least 3 distinct concepts, which has resulted in confusion surrounding this topic. We propose precise definitions of these different concepts of immune correlates, using the nomenclature ""correlate of risk,"" ""level 1 surrogate of protection,"" and ""level 2 surrogate of protection."" We suggest a general framework for assessing these 3 levels of immune correlates in vaccine efficacy trials. To demonstrate the proposed principles, we analyze data from a 1943 influenza vaccine field trial, supporting Weiss strain A-specific antibody titers as a level 1 surrogate of protection. Other real and simulated examples are also discussed.
With the publicly available data in the CAVD DataSpace we can Learn about studies, products, assays, antibodies, and publications, Find subjects with common characteristics, Plot assay results across studies and years of research, and Compare monoclonal antibodies and their neutralization curves. Data are also accessible via DataSpaceR, our R API.
Sign in to see full information about this publication and to download study data when available.
Related Studies
No related studies