Overview
Publication
Curr Opin HIV AIDS. 2009 Sep; 4(5):373-9.
PubMed ID: 20048700
Title
HIV-1-specific antibody responses during acute and chronic HIV-1 infection
Authors
Tomaras GD, Haynes BF
Abstract
The humoral immune response to HIV-1 throughout infection is comprised of complex mixtures of antibody isotypes with numerous HIV-1 specificities. However, unlike antibody responses to most infections, protective antibody responses are delayed and do not arise until long after HIV-1 latency is established. We review recent data on HIV-1-specific antibody isotypes induced following HIV-1 transmission: to understand the effects of HIV-1 on B cell and T cell effector responses, to understand the timing of the rise and fall of different anti-HIV-1 antibodies and to understand how antibodies could contribute to protective immunity if they were either pre-existing or elicited immediately after HIV-1 transmission.
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