Overview
Publication
PLOS ONE. 2010 Apr 21; 5(4):e10254.
PubMed ID: 20421997
Title
Anti-V3 monoclonal antibodies display broad neutralizing activities against multiple HIV-1 subtypes
Authors
Hioe CE, Wrin T, Seaman MS, Yu X, Wood B, Self S, Williams C, Gorny MK, Zolla-Pazner S
Abstract
The V3 loop of the HIV-1 envelope (Env) glycoprotein gp120 was identified as the ""principal neutralizing domain"" of HIV-1, but has been considered too variable to serve as a neutralizing antibody (Ab) target. Structural and immunochemical data suggest, however, that V3 contains conserved elements which explain its role in binding to virus co-receptors despite its sequence variability. Despite this evidence of V3 conservation, the ability of anti-V3 Abs to neutralize a significant proportion of HIV-1 isolates from different subtypes (clades) has remained controversial.
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