Overview
Publication
AIDS. 2010 Oct 23; 24(16):2527-33.
PubMed ID: 20683317
Title
Flexible use of CCR5 in the absence of CXCR4 use explains the immune deficiency in HIV-1 infected children
Authors
Cavarelli M, Karlsson I, Ripamonti C, Plebani A, Fenyo EM, Scarlatti G
Abstract
CCR5-using HIV-1 (R5 viruses) are usually isolated during acute infection from both adults and children. We have recently demonstrated that R5 viruses with a flexible use of CCR5 (called R5broad) can be detected in children close to birth and are predictive of a fast immunological failure. The aim of the present work was to investigate viral phenotype variation during disease progression in HIV-1 infected children, six slow and eight fast progressors.
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