Overview
Publication
Curr Opin HIV AIDS. 2010 Sep; 5(5):421-7.
PubMed ID: 20978384
Title
Strategies for eliciting HIV-1 inhibitory antibodies
Authors
Tomaras GD, Haynes BF
Abstract
Major roadblocks persist in the development of vaccines that elicit potent neutralizing antibodies targeting diverse HIV-1 strains, similar to known broadly neutralizing HIV-1 human monoclonal antibodies. Alternatively, other types of anti-HIV-1 envelope antibodies that may not neutralize HIV-1 in traditional neutralization assays but have other anti-HIV-1 activities (hereafter termed HIV-1 inhibitory antibodies) can be elicited by current vaccine strategies, and numerous studies are exploring their roles in preventing HIV-1 acquisition. We review examples of strategies for eliciting potentially protective HIV-1 inhibitory antibodies.
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