Overview
Publication
Bioinformatics. 2010 Apr 1; 26(7):867-72.
PubMed ID: 20147303
Title
SoDA2: A Hidden Markov Model approach for identification of immunoglobulin rearrangements
Authors
Munshaw S, Kepler TB
Abstract
The inference of pre-mutation immunoglobulin (Ig) rearrangements is essential in the study of the antibody repertoires produced in response to infection, in B-cell neoplasms and in autoimmune disease. Often, there are several rearrangements that are nearly equivalent as candidates for a given Ig gene, but have different consequences in an analysis. Our aim in this article is to develop a probabilistic model of the rearrangement process and a Bayesian method for estimating posterior probabilities for the comparison of multiple plausible rearrangements.
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