Overview
Publication
AIDS. 2010 Sep 10; 24(14):2151-60.
PubMed ID: 20647906
Title
Increased plasmacytoid dendritic cell maturation and natural killer cell activation in HIV-1 exposed, uninfected intravenous drug users
Authors
Tomescu C, Duh FM, Lanier MA, Kapalko A, Mounzer KC, Martin MP, Carrington M, Metzger DS, Montaner LJ
Abstract
Increased natural killer (NK) activation has been associated with resistance to HIV-1 infection in several cohorts of HIV-1 exposed, uninfected individuals. Inheritance of protective NK receptor alleles (KIR3DS1 and KIR3DL1) has also been observed in a subset of HIV-1 exposed, uninfected individuals. However, the exact mechanism contributing to NK activation in HIV-1 exposed, uninfected intravenous drug users (EU-IDU) remains to be elucidated.
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