Overview
Publication
Curr Opin HIV AIDS. 2012 Jan; 7(1):32-7.
PubMed ID: 22134340
Title
Profiling immunity to HIV vaccines with systems biology
Authors
Andersen-Nissen E, Heit A, McElrath MJ
Abstract
The recent modest success of the RV144 HIV vaccine trial in Thailand has shown that development of an HIV vaccine is possible. Designing a vaccine that achieves better protection, however, will require a more complete understanding of vaccine mechanisms of action and correlates of protection. Systems biology approaches enable integration of large datasets from a variety of assays and offer new approaches to understanding how vaccine-induced immune responses are coordinately regulated. In this review, we discuss the recent advances in clinical trial design, specimen collection, and assay standardization that will generate datasets for systems analyses of immune responses to HIV vaccines.
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