Overview
Publication
Curr Opin HIV AIDS. 2012 Jan; 7(1):24-31.
PubMed ID: 22156839
Title
Systems vaccinology: Its promise and challenge for HIV vaccine development
Authors
Nakaya HI, Pulendran B
Abstract
The use of systems biology approaches to understand and predict vaccine-induced immunity promises to revolutionize vaccinology. For centuries vaccines were developed empirically, with very little understanding of the mechanisms by which they mediate protective immunity. The so-called systems vaccinology approach employs high-throughput technologies (e.g. microarrays, RNA-seq and mass spectrometry-based proteomics and metabolomics) and computational modeling to describe the complex interactions between all the parts of immune system, with a view to elucidating new biological rules capable of predicting the behavior of the system.
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