Overview
Publication
J Virol. 2013 May; 87(9):5287-90.
PubMed ID: 23408628
Title
Antibody-DEPENDENT, FcgRI-mediated neutralization of HIV-1 in TZM-bl cells occurs independently of phagocytosis
Authors
Perez LG, Zolla-Pazner S, Montefiori DC
Abstract
We previously showed that expression of human FcγRI on TZM-bl cells potentiates neutralization by gp41 membrane-proximal external region (MPER)-specific antibodies. Here we show that lysosomotropic reagents known to block phagocytosis do not diminish this effect. We also show that FcγRI occasionally potentiates neutralization by antibodies against the V3 loop of gp120 and cluster I of gp41. We conclude that FcγRI provides a kinetic advantage for neutralizing antibodies against partially cryptic epitopes independent of phagocytosis.
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