Overview
Publication
PLOS ONE. 2012; 7(12):e51715.
PubMed ID: 23300558
Title
An automated HIV-1 Env-pseudotyped virus production for global HIV vaccine trials
Authors
Schultz A, Koch S, Fuss M, Mazzotta AS, Sarzotti-Kelsoe M, Ozaki DA, Montefiori DC, von Briesen H, Zimmermann H, Meyerhans A
Abstract
Infections with HIV still represent a major human health problem worldwide and a vaccine is the only long-term option to fight efficiently against this virus. Standardized assessments of HIV-specific immune responses in vaccine trials are essential for prioritizing vaccine candidates in preclinical and clinical stages of development. With respect to neutralizing antibodies, assays with HIV-1 Env-pseudotyped viruses are a high priority. To cover the increasing demands of HIV pseudoviruses, a complete cell culture and transfection automation system has been developed.
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