Overview
Publication
Bioinformatics. 2013 Feb 15; 29(4):461-7.
PubMed ID: 23267174
Title
Data exploration, quality control and testing in single-cell qPCR-based gene expression experiments
Authors
McDavid A, Finak G, Chattopadyay PK, Dominguez M, Lamoreaux L, Ma SS, Roederer M, Gottardo R
Abstract
Cell populations are never truly homogeneous; individual cells exist in biochemical states that define functional differences between them. New technology based on microfluidic arrays combined with multiplexed quantitative polymerase chain reactions now enables high-throughput single-cell gene expression measurement, allowing assessment of cellular heterogeneity. However, few analytic tools have been developed specifically for the statistical and analytical challenges of single-cell quantitative polymerase chain reactions data.
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