Overview
Publication
AIDS Res Hum Retroviruses. 2012 Apr; 28(4):400-4.
PubMed ID: 21902593
Title
Evaluating immune correlates in HIV type 1 vaccine efficacy trials: What RV144 may provide
Authors
Rolland M, Gilbert P
Abstract
Since the RV144 vaccine combination showed efficacy in a Phase III trial, it provides an opportunity to generate hypotheses about the immune responses necessary for protection against HIV-1 infection, and these results could help devise vaccine candidates with higher efficacy. Here we describe how researchers can determine the correlates of immune protection for an HIV/AIDS vaccine, particularly in the context of the RV144 trial, and we discuss the terminology used to describe correlates and surrogates.
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