Overview
Publication
AIDS. 2014 Jan 14; 28(2):163-9.
PubMed ID: 24361678
Title
Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection
Authors
Hraber P, Seaman MS, Bailer RT, Mascola JR, Montefiori DC, Korber BT
Abstract
Studies of neutralizing antibodies in HIV-1 infected individuals provide insights into the quality of the response that should be possible to elicit with vaccines and ways to design effective immunogens. Some individuals make high titres of exceptional broadly reactive neutralizing antibodies that are of particular interest; however, more modest responses may be a reasonable goal for vaccines. We performed a large cross-sectional study to determine the spectrum of neutralization potency and breadth that is seen during chronic HIV-1 infection.
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