Overview
Publication
J Acquir Immune Defic Syndr. 2014 Aug 15; 66(5):473-83.
PubMed ID: 24853313
Title
Rational design and characterization of the novel, broad and potent bispecific HIV-1 neutralizing antibody iMabm36
Authors
Sun M, Pace CS, Yao X, Yu F, Padte NN, Huang Y, Seaman MS, Li Q, Ho DD
Abstract
Although broadly neutralizing monoclonal antibodies (bNAbs) have always been considered to be a potential therapeutic option for the prophylaxis and treatment of HIV infection, their lack of breadth against all HIV variants has been one of the limiting factors. To provide sufficient neutralization breadth and potency against diverse viruses, including neutralization escape mutants, strategies to combine different bNAbs have been explored recently.
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