Overview
Publication
Retrovirology. 2013 Oct 24; 10(NA):117.
PubMed ID: 24156704
Title
GagPol-specific CD4+ T-cells increase the antibody response to Env by intrastructural help
Authors
Nabi G, Genannt Bonsmann MS, Tenbusch M, Gardt O, Barouch DH, Temchura V, Uberla K
Abstract
Immunization of rhesus macaques against Gag of SIV resulted in a more rapid appearance of Env antibodies after infection with SIV or SHIV challenge viruses although the vaccines lacked an Env component. We therefore explored whether T helper cells specific for internal HIV proteins could provide intrastructural help for Env-specific B cells and thus increase the Env antibody response.
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