Overview
Publication
Retrovirology. 2013 Dec 5; 10(NA):147.
PubMed ID: 24304511
Title
Allosteric induction of the CD4-bound conformation of HIV-1 Gp120
Authors
Roitburd-Berman A, Dela G, Kaplan G, Lewis GK, Gershoni JM
Abstract
HIV-1 infection of target cells is mediated via the binding of the viral envelope protein, gp120, to the cell surface receptor CD4. This interaction leads to conformational rearrangements in gp120 forming or revealing CD4 induced (CD4i) epitopes which are critical for the subsequent recognition of the co-receptor required for viral entry. The CD4-bound state of gp120 has been considered a potential immunogen for HIV-1 vaccine development. Here we report on an alternative means to induce gp120 into the CD4i conformation.
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