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Studies / CAVD 475


Study information

Grant Affiliation:Hu: Unmasking Conserved Epitopes
Strategy:Vector vaccines (viral or bacterial)
Study Type:Pre-Clinical Non-NHP
Stage:Assays Completed
Study Start Date:2014-12-19
Study Made Public:2015-06-19


Study to determine whether Env immunogen binding to human CD4 affects immunogenicity - Mouse Immunogenicity Study 7 Revised (MU7R)


CAVD 475 (MU7R) is a preclinical mouse study to determine whether the presence of huCD4 affects immunogenicity by comparing huCD4 transgenic mice versus BL/6 mice immunized with either 89.6 WT Env, CD4-independent Envelope containing a CD4 binding site [CD4i 89.6 N7 (D4T)], or CD4-independent Envelope lacking a CD4 binding site [CD4i 89.6 (A2)].


v-NY-89.6 WT Env gp160 v-NY-CD4i 89.6 N7 Env gp160 (D4T) v-NY-CD4i 89.6 Env gp160 (A2) v-NY-SIV gag/pol

Integrated data

No integrated data is available for this study.

Non-integrated data

No non-integrated data is available for this study.