Looking for data on a recent publication? Trying to figure out how to make your publication data accessible?

DataSpace now provides analysis datasets on the publication pages in Learn. The Learn section offers detailed information and metadata regarding data found in DataSpace. The Publications section in Learn is a compilation of CAVD and HVTN manuscripts (plus a few other publications for related trials like RV144). Each publication has its own publication page. The data used for these publications can now be posted to and downloaded from the publication pages. In addition to the analysis datasets, the publication data zip file contains annotation such as a data dictionary, README file, and analysis code (when available). Links to the publication data can be included in the journal article or on other platforms.

So far, we've posted publication datasets for 10 HVTN publications and hope to make posting publication data a routine part of the publication process for future CAVD and HVTN studies. The publications for which we currently have data posted are listed below:

2020

• Hosseinipour 2020 (Clin Infect Dis) — Phase 1 HIV vaccine trial to evaluate the safety and immunogenicity of HIV subtype C DNA and MF59-adjuvanted subtype C Env protein. HVTN 111.
• Westling 2020 (J R Stat Soc) — Causal isotonic regression. Multiple study meta-analysis.

2019

• Cram 2019 (PLOS One) — Human gut microbiota is associated with HIV-reactive immunoglobulin at baseline and following HIV vaccination. HVTN 096. Note: File size is very large.
• Pantaleo 2019 (Lancet HIV) — Safety and immunogenicity of a multivalent HIV vaccine comprising envelope protein with either DNA or NYVAC vectors (HVTN 096): a phase 1b, double-blind, placebo-controlled trial. HVTN 096.
• Rouphael 2019 (J Clin Invest) — DNA priming and gp120 boosting induces HIV-specific antibodies in a randomized clinical trial. HVTN 105.

​2018

• Bekker 2018 (Lancet HIV) — A phase 1/2 HIV-1 vaccine trial of a Subtype C ALVAC-HIV and Bivalent Subtype C gp120/MF59 vaccine regimen in low risk HIV uninfected South African adults. HVTN 100.
• Fong 2018 (J Infect Dis) — Modification of the association between T-Cell immune responses and human immunodeficiency virus type 1 infection risk by vaccine-induced antibody responses in the HVTN 505 trial. HVTN 505.

​2017

• Janes 2017 (J Infect Dis) — Higher T-Cell responses induced by DNA/rAd5 HIV-1 preventive vaccine are associated with lower HIV-1 infection risk in an efficacy trial. HVTN 505.
• Mayer 2017 (PLOS Med) — Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adults: Results of a phase 1 randomized trial. HVTN 104.

2013

• Hammer 2013 (N Engl J Med) — Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine. HVTN 505.

R user pro tip: The publication datasets can be accessed programmatically via the DataSpaceR API. Check out our vignette on how to access publication data using DataSpaceR. Once you've installed the DataSpaceR package, you can also use the following R command for quick access to the vignette:

vignette(topic="Publication_Data", package="DataSpaceR")

Want to learn more?

We're happy to help you post your publication data or find data from a publication. Contact us at [email protected].